Motif ID: FOX{C1,C2}.p2

Z-value: 1.466


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXC2chr16_+_866008560.371.9e-08Click!
FOXC1chr6_+_16106800.152.3e-02Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_189839132 46.868 COL3A1
collagen, type III, alpha 1
chr2_+_189839078 40.766 NM_000090
 COL3A1
collagen, type III, alpha 1
chr2_+_189839113 40.350 COL3A1
collagen, type III, alpha 1
chr3_+_133495925 28.126 TF
transferrin
chr12_+_69742130 25.466 NM_000239
 LYZ
lysozyme
chr12_+_69742140 25.156 LYZ
lysozyme
chr2_+_74120132 24.051 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_+_74120092 23.718 NM_001199893
NM_001615
 ACTG2

actin, gamma 2, smooth muscle, enteric

chr14_+_95047758 22.582 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr3_-_114343791 22.447 NM_001164346
 ZBTB20
zinc finger and BTB domain containing 20
chr10_+_7745341 21.562 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_+_74281884 20.092 ALB
albumin
chr9_-_104198045 18.618 NM_000035
 ALDOB
aldolase B, fructose-bisphosphate
chr17_-_64225496 18.413 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr10_+_7745354 18.284 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr14_+_95047730 17.928 NM_000624
 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr17_-_48271365 17.655


chr10_+_7745284 17.210 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745325 17.075 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chrX_+_138612894 16.130 NM_000133
 F9
coagulation factor IX

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
9.57 4.45e-02 GO:0046427 positive regulation of JAK-STAT cascade
6.73 9.89e-03 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
4.09 1.32e-02 GO:0051251 positive regulation of lymphocyte activation
3.81 2.95e-02 GO:0002696 positive regulation of leukocyte activation
3.74 3.57e-02 GO:0050867 positive regulation of cell activation
3.70 1.10e-02 GO:0051249 regulation of lymphocyte activation
3.57 9.28e-03 GO:0002694 regulation of leukocyte activation
3.43 1.55e-02 GO:0050865 regulation of cell activation
2.62 1.80e-02 GO:0009967 positive regulation of signal transduction
2.50 3.96e-02 GO:0010647 positive regulation of cell communication
2.48 4.38e-02 GO:0023056 positive regulation of signaling
2.28 3.72e-02 GO:0002682 regulation of immune system process
2.25 2.51e-02 GO:0006955 immune response
2.15 3.59e-04 GO:0002376 immune system process
2.12 2.74e-02 GO:0009611 response to wounding
2.10 1.89e-02 GO:0042127 regulation of cell proliferation
2.03 2.52e-03 GO:0051239 regulation of multicellular organismal process
1.92 7.16e-03 GO:0009966 regulation of signal transduction
1.82 2.36e-03 GO:0048583 regulation of response to stimulus
1.75 2.29e-02 GO:0007166 cell surface receptor linked signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
23.92 3.68e-02 GO:0045179 apical cortex
2.82 1.79e-02 GO:0005578 proteinaceous extracellular matrix
2.79 5.46e-03 GO:0031012 extracellular matrix
2.51 2.85e-05 GO:0005615 extracellular space
2.48 7.91e-09 GO:0031226 intrinsic to plasma membrane
2.48 1.08e-08 GO:0005887 integral to plasma membrane
2.42 1.74e-06 GO:0044421 extracellular region part
2.16 5.62e-10 GO:0005576 extracellular region
1.95 2.57e-07 GO:0044459 plasma membrane part
1.64 4.22e-08 GO:0071944 cell periphery
1.62 2.83e-07 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
9.57 4.85e-04 GO:0003823 antigen binding
4.02 3.25e-02 GO:0046906 tetrapyrrole binding
2.95 9.38e-03 GO:0016563 transcription activator activity
2.21 2.00e-02 GO:0005509 calcium ion binding
1.82 1.25e-03 GO:0004872 receptor activity
1.78 4.95e-02 GO:0004888 transmembrane receptor activity
1.71 1.80e-03 GO:0004871 signal transducer activity
1.71 1.80e-03 GO:0060089 molecular transducer activity